Melanotan II (MT-II) is a synthetic alpha-melanocyte-stimulating hormone (α-MSH) analogue that researchers study for metabolic regulation, appetite suppression, and melanogenesis. MT-II activates melanocortin receptors (particularly MC1R and MC3R/MC4R), triggering a cascade of effects on pigmentation, metabolic rate, and appetite control. The peptide crosses the blood-brain barrier, allowing central and peripheral effects.
Research applications span obesity and metabolic disorder models, examining MT-II’s appetite-suppressing and thermogenic properties. Investigators also study Melanotan II for its direct pigmentation effects and skin photoprotection mechanisms. The peptide’s central melanocortin pathway activation offers insights into metabolic regulation and energy homeostasis physiology.
Melanotan II exhibits rapid onset and potent bioactivity, making it valuable for acute-effect studies and chronic-exposure protocols. The peptide has demonstrated benefits for metabolic markers, body composition, and energy expenditure in research models. Careful experimental parameters and monitoring are essential, as excessive melanocortin activation can produce unwanted effects.
**Specifications:**
– **Purity:** ≥99% (HPLC verified)
– **Form:** Lyophilized powder
– **Storage:** 2–8°C (refrigerated); -20°C for extended storage
– **CAS#:** 121062-08-6
*For research use only. Not for human consumption.*
Independent Janoshik COA in progress – expected July 24, 2026.
